Eufluxxa Injection

Euflexxa is a synthetic form of hyaluronan. Hyaluronan is a thick, elastic substance that naturally exists in healthy joint fluid. When osteoarthritis develops, this fluid becomes thinner and less effective at cushioning and protecting the joint.

Injecting this treatment directly into the joint can help in several ways. It improves lubrication so the joint moves more smoothly. It provides shock absorption, which reduces stress on the cartilage. It also has anti-inflammatory and pain-relieving effects. Over time, it can help the joint produce healthier, non-inflamed fluid and protect the cartilage that remains.

This injection can be used in many joints, including the knee, hip, ankle and foot. It is also suitable for the shoulder, elbow, wrist and the base of the thumb.

The treatment


This type of injection works best when the joint is not swollen or highly inflamed. If there is excess fluid in the joint, your doctor will usually recommend having it aspirated and treated with cortisone two to four weeks before starting treatment. They can include a referral for an ultrasound-guided aspiration at the same time they refer you for the injections.

The procedure is performed under CT guidance in a sterile environment by one of our Radiologist. Treatment involves a series of three injections, given two weeks apart. Each appointment takes about 15 minutes and you can drive yourself home afterward.

At your first appointment, any excess joint fluid will be removed through the same needle that is then used to administer the injection. After each treatment, you should rest the joint as much as possible for the next 48 hours. Avoid activities that increase your pain or put extra stress on the joint.

You can expect the full effect of the treatment around eight weeks after the first injection. For many people, the benefits last longer than six months. The treatment can be safely repeated twice a year if needed.

Side effects and risks


It’s common to experience short-term side effects such as mild joint swelling, stiffness, bruising or temporary pain at the injection site. These usually settle within a few days.

Infection is rare, but it’s important to know the warning signs. If you develop a fever along with joint pain, redness, swelling or warmth within a week of your injection, contact your doctor and our clinic straight away.

If you have any questions or concerns at any stage, you’re always welcome to call us.

Euflexxa is supported by several major clinical bodies, including the International Osteoarthritis Research Society, the European League Against Rheumatism, the American College of Rheumatology and the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO), all of which recommend its use for symptomatic osteoarthritis.

Forming your road to recovery